Article
Homogeneous time-resolved fluorescence assay for identifying p53 interactions with its protein partners, directly in a cellular extract.
Analytical biochemistry - 15 Sept 2002
Leblanc Virginie, Delaunay Valérie, Claude Lelong Jean, Gas Fabienne, Mathis Gérard, Grassi Jacques, May Evelyne
Abstract excerpt
The p53 protein is a tumor suppressor that protects the organism against malignant consequences of DNA damage. Interaction of p53 with numerous cellular or viral proteins regulates its functional activity either positively or negatively. An approach leading to identification of such protein interactions directly in a cell extract could be of help in the development of screening assays to search for drugs acting...
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