Article
Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.
Neuro-oncology - 1 Sept 2017
Takayanagi Shunsaku, Mukasa Akitake, Tanaka Shota, Nomura Masashi, Omata Mayu, Yanagisawa Shunsuke, Yamamoto Shogo, Ichimura Koichi, Nakatomi Hirofumi, Ueki Keisuke, Aburatani Hiroyuki, Saito Nobuhito
Abstract excerpt
Background: Although inactivation of the von Hippel-Lindau gene (VHL), located on chromosome 3p25, is considered to be a major cause of hemangioblastomas (HBs), the incidence of biallelic inactivation of VHL is reportedly low. The aim of this study was to determine the prevalence of VHL alterations in HBs, as well as to identify additional molecular aberrations. Methods: Genetic and epigenetic alterations were...
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