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Article

Somatic mutational landscape in von Hippel-Lindau familial hemangioblastoma.

Molecular oncology - 1 Aug 2026

Dembic Maja, Nørremølle Anne, Ousager Lilian Bomme, van Brakel Andersen Lars, Binderup Marie Louise Mølgaard, Thomassen Mads

Abstract excerpt

Von Hippel-Lindau disease (vHL) predisposes to tumor development, mainly clear cell renal carcinoma and hemangioblastoma. The underlying cause is germline variants in the VHL gene, with tumorigenesis thought to require additional somatic 'second-hit' events that most commonly include loss of 3p. However, the precise mechanisms of vHL-related tumor development remain incompletely understood. Genomic investigations...

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Share to VHL gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 41870981
DOI: 10.1002/1878-0261.70228
PMCID: PMC13398559

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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