Article
Large hepatitis delta antigen is phosphorylated at multiple sites and phosphorylation is associated with protein conformational change.
Intervirology - 1 Jan 2002
Choi Soo-Ho, Park Kyu-Jin, Hwang Soon B
Abstract excerpt
Hepatitis delta antigen (HDAg) consists of two species, small HDAg (SHDAg) and large HDAg (LHDAg), which are identical in sequence with the exception that the large form contains an additional 19 amino acids at the C-terminus. Both HDAgs are nuclear phosphoproteins. However, LHDAg is hyperphosphorylated, i.e. it is at least 10 times more phosphorylated than SHDAg. To determine the phosphorylation site(s) of the...
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