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Article

ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication.

Journal of virology - 1 Oct 2008

Chen Yen-Shun, Huang Wen-Hung, Hong Shiao-Ya, Tsay Yeou-Guang, Chen Pei-Jer

Abstract excerpt

The small hepatitis delta virus (HDV) antigen (SHDAg) plays an essential role in HDV RNA double-rolling-circle replication. Several posttranslational modifications (PTMs) of HDAgs, including phosphorylation, acetylation, and methylation, have been characterized. Among the PTMs, the serine 177 residue of SHDAg is a phosphorylation site, and its mutation preferentially abolishes HDV RNA replication from antigenomic...

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Identifiers

PMID: 18632853
DOI: 10.1128/JVI.00656-08
PMCID: PMC2546944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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