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Article

Synergistic induction of apoptosis by acyclic retinoid and interferon-β in human hepatocellular carcinoma cells

1 Nov 2002

Abstract excerpt

Acyclic retinoid, a synthetic retinoid analog, as well as interferon alfa (IFN-alpha) and IFN-beta induce apoptosis in hepatocellular carcinoma (HCC) cells and are used clinically in the prevention of HCC. Here, we show that acyclic retinoid acts synergistically with IFNs in suppressing the growth and inducing apoptosis (as characterized by DNA fragmentation and chromatin condensation) in 5 human HCC cell lines...

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PMID: 12395321
DOI: 10.1053/jhep.2002.36369

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