Article
A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopenia.
Blood - 1 Feb 2003
Peterson Julie A, Nyree Contessa E, Newman Peter J, Aster Richard H
Abstract excerpt
Drug-dependent antibodies (DDAbs) can cause the precipitous destruction of platelets if a patient is exposed to the drug for which the antibodies are specific. The molecular character of the epitopes recognized is poorly understood, and the mechanism by which drugs promote tight binding of these antibodies to platelet glycoproteins without linking covalently to protein or antibody is not yet known. We studied a...
Topics
- Amino Acid Sequence
- Animals
- Antibodies
- Antibody Affinity
- Epitopes
- Humans
- Integrin beta3
- Molecular Sequence Data
- Mutation
- Quinine
- Rats
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid
- Species Specificity