Quinine-dependent antibodies to neutrophils react with a 60-Kd glycoprotein on which neutrophil-specific antigen NB1 is located and an 85-Kd glycosyl-phosphatidylinositol-linked N-glycosylated plasma membrane glycoprotein.

Abstract excerpt

We have previously described a 24-year-old woman with quinine-dependent antibodies that reacted with neutrophils, red blood cells (RBCs), platelets, and T lymphocytes. The drug-dependent neutrophil antibody was found to react with 85- and 60-Kd neutrophil membrane molecules. In these studies, we...

Topics

• Adult
• Antibodies
• Antigen-Antibody Complex
• Cell Membrane
• Complement C5a
• Electrophoresis, Polyacrylamide Gel
• Female
• Glycosylphosphatidylinositols
• Humans
• In Vitro Techniques
• Membrane Proteins
• Molecular Weight
• N-Formylmethionine Leucyl-Phenylalanine
• Neutrophils
• Phenotype
• Phosphatidylinositol Diacylglycerol-Lyase
• Phosphoric Diester Hydrolases
• Quinine