Article
Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor.
Blood - 15 Nov 2002
Davies Stella M, Ruggieri Loredana, DeFor Todd, Wagner John E, Weisdorf Daniel J, Miller Jeffrey S, Velardi Andrea, Blazar Bruce R
Abstract excerpt
One of the functions of HLA class I alleles is interaction with natural killer (NK) cells. Receptors termed killer immunoglobulin-like receptors (KIRs) on NK cells recognize groups of HLA class I alleles, and interaction between receptor and class I allele inhibits reactivity of the NK cell. Failure to recognize the appropriate KIR ligand on a mismatched cell can trigger NK cell elimination of that target cell....
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