Article
KIR/HLA ligand incompatibility in kidney transplantation.
Transplantation - 15 Dec 2007
Kunert Kristina, Seiler Marleen, Mashreghi Mir Farzin, Klippert Katrin, Schönemann Constanze, Neumann Konrad, Pratschke Johann, Reinke Petra, Volk Hans-Dieter, Kotsch Katja
Abstract excerpt
BACKGROUND: The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts beneficial effects in hematopoietic stem cell transplantation. METHODS: To elucidate whether certain...
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