Article
Sequence variation in the Trichuris trichiura beta-tubulin locus: implications for the development of benzimidazole resistance.
International journal for parasitology - 1 Nov 2002
Bennett A B, Anderson T J C, Barker G C, Michael E, Bundy D A P
Abstract excerpt
Benzimidazole resistance has evolved in a variety of organisms and typically results from mutations in the beta-tubulin locus at specific amino acid sites. Despite widespread treatment of human intestinal nematodes with benzimidazole drugs, there have been no unambiguous reports of resistance. However, since beta-tubulin mutations conferring resistance are generally recessive, frequencies of resistance alleles...
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