Sequence variation in the Trichuris trichiura beta-tubulin locus: implications for the development of benzimidazole resistance.

doi:10.1016/s0020-7519(02)00155-8

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Article

Sequence variation in the Trichuris trichiura beta-tubulin locus: implications for the development of benzimidazole resistance.

International journal for parasitology - 1 Nov 2002

Bennett A B, Anderson T J C, Barker G C, Michael E, Bundy D A P

Abstract excerpt

Benzimidazole resistance has evolved in a variety of organisms and typically results from mutations in the beta-tubulin locus at specific amino acid sites. Despite widespread treatment of human intestinal nematodes with benzimidazole drugs, there have been no unambiguous reports of resistance. However, since beta-tubulin mutations conferring resistance are generally recessive, frequencies of resistance alleles...

Topics

Animals
Antiparasitic Agents
Benzimidazoles
Drug Resistance
Evolution, Molecular
Gene Expression Regulation
Genes, Helminth
Genetic Variation
Mutation
Polymorphism, Genetic
Population Density
Trichuris
Tubulin

Source

Open in PubMed

Identifiers

PMID: 12392917
DOI: 10.1016/s0020-7519(02)00155-8

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