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Article

Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment.

International journal for parasitology. Drugs and drug resistance - 1 Dec 2024

Gandasegui Javier, Grau-Pujol Berta, Novela Valdemiro, Muchisse Osvaldo, Cambra-Pellejà Maria, Cossa Anélsio, Jamine José Carlos, Sacoor Charfudin, Brienen Eric A T, Catala-Moll Francesc, van Lieshout Lisette, Martínez-Valladares María, Paredes Roger, Muñoz José, Doyle Stephen R

Abstract excerpt

Concerns about the emergence of benzimidazole resistance in soil-transmitted helminths (STH) infections, particularly against Trichuris trichiura, have arisen. Previous studies of veterinary nematodes have linked benzimidazole resistance to single-nucleotide polymorphisms (SNPs) at three specific codons in the beta-tubulin gene, but similar associations in STH have not been consistently observed. In this work, we...

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Identifiers

PMID: 39546832
DOI: 10.1016/j.ijpddr.2024.100570
PMCID: PMC11607648

Genes

STH

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