Article
Identification of second-site mutations that enhance release and spread of vaccinia virus.
Journal of virology - 1 Nov 2002
Katz Ehud, Wolffe Elizabeth, Moss Bernard
Abstract excerpt
The spread of most strains of vaccinia virus in cell monolayers occurs predominantly via extracellular enveloped virions that adhere to the tips of actin-containing microvilli and to a lesser extent via diffusion of released virions. The mechanism by which virions adhere to the cell surface is unknown, although several viral proteins may be involved. The present investigation was initiated with the following...
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