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Article

Mitogen‐inducible gene 6 (MIG‐6), adipophilin and tuftelin are inducible by hypoxia

28 Sept 2002

Abstract excerpt

Adaptation to hypoxia is essential for tumor progression. Transcriptional activation of hypoxia-regulated genes is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimer of HIF-1alpha and ARNT (Ah receptor nuclear translocator; HIF-1beta). Using representational difference analysis, we identified three novel hypoxia-inducible genes: MIG-6 (gene 33), adipophilin and tuftelin. The mRNAs for these genes were...

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PMID: 12387890
DOI: 10.1016/s0014-5793(02)03475-0

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