Article
Involvement of Proteasome in the Dynamic Assembly of the Androgen Receptor Transcription Complex
1 Dec 2002
Abstract excerpt
We have used the chromatin immunoprecipitation technique to analyze the formation of the androgen receptor (AR) transcription complex onto prostate-specific antigen (PSA) and kallikrein 2 promoters in LNCaP cells. Our results show that loading of holo-AR and recruitment of RNA polymerase II to the promoters occur transiently. The cyclic nature of AR transcription complex assembly is also illustrated by transient...
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