Article
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2002
Aoki-Nagase Tomoko, Nagase Takahide, Oh-Hashi Yoshio, Shindo Takayuki, Kurihara Yukiko, Yamaguchi Yasuhiro, Yamamoto Hiroshi, Tomita Tetsuji, Ohga Eijiro, Nagai Ryozo, Kurihara Hiroki, Ouchi Yasuyoshi
Abstract excerpt
Bronchial hyperresponsiveness and eosinophilia are major characteristics of asthma. Calcitonin gene-related peptide (CGRP) is a neuropeptide that has various biological actions. In the present study, we questioned whether CGRP might have pathophysiological roles in airway hyperresponsiveness and eosinophilia in asthma. To determine the exact roles of endogenous CGRP in vivo, we chose to study antigen-induced...
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