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Phenotypic plasticity in parotid tumours: insights from a surgical oncologist's perspective.

BMJ case reports - 4 Dec 2024

Kushwaha Naveen Kumar, Jaiswal Pradeep, Murthy Harish Shiva, Dhaman Pawan Kumar

Abstract excerpt

Phenotypic plasticity refers to the ability of tumour cells to undergo molecular and phenotypic changes in response to microenvironmental stresses, genetic and epigenetic alterations, or treatment-induced selective pressures, thereby promoting tumour progression. This case report discusses a man in his 70s with pleomorphic adenoma of the parotid, where phenotypic plasticity led to the development of pleomorphic...

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PMID: 39631904
DOI: 10.1136/bcr-2023-259115

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