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Modulation of the Cell Division Cycle by Human Papillomavirus Type 18 E4

4 Oct 2002

Abstract excerpt

The life cycle of human papillomaviruses (HPVs) is tightly coupled to the differentiation program of their host epithelial cells. HPV E4 gene expression is first observed in the parabasal layers of squamous epithelia, suggesting that the E4 gene product contributes to the mechanism of differentiation-dependent virus replication, although its biological function remains unclear. We analyzed the effect of HPV type...

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PMID: 12368334
DOI: 10.1128/jvi.76.21.10914-10920.2002

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