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Identification of a G <sub>2</sub> Arrest Domain in the E1∧E4 Protein of Human Papillomavirus Type 16

3 Sept 2002

Abstract excerpt

Human papillomavirus type 16 (HPV16) is the most common cause of cervical carcinoma. Cervical cancer develops from low-grade lesions that support the productive stages of the virus life cycle. The 16E1 wedge E4 protein is abundantly expressed in such lesions and can be detected in cells supporting vegetative viral genome amplification. Using an inducible mammalian expression system, we have shown that 16E1 wedge...

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PMID: 12208959
DOI: 10.1128/jvi.76.19.9806-9818.2002

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