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Article

Polymers and inflammation: disease mechanisms of the serpinopathies.

The Journal of experimental medicine - 7 Jul 2008

Gooptu Bibek, Lomas David A

Abstract excerpt

Members of the serpin (serine proteinase inhibitor) superfamily play a central role in the control of inflammatory, coagulation, and fibrinolytic cascades. Point mutations that cause abnormal conformational transitions in these proteins can trigger disease. Recent work has defined three pathways by which these conformers cause tissue damage. Here, we describe how these three mechanisms can be integrated into a...

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Identifiers

PMID: 18591408
DOI: 10.1084/jem.20072080
PMCID: PMC2442629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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