Article
Kinetic regulation of beta 3 integrin tyrosine phosphorylation.
The Journal of biological chemistry - 6 Dec 2002
Blystone Scott D
Abstract excerpt
Tyrosine phosphorylation of beta(3) integrins is a permissive stage in the activation of alpha(IIb)beta(3) and alpha(v)beta(3) in platelets and leukocytes, respectively. In this study we demonstrated direct phosphorylation of beta(3) integrins as a result of interaction with soluble monomeric ligand, and we characterized the differential kinetics of beta(3) phosphorylation as a consequence of alpha subunit...
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