Article
T cell-specific expression of the murine CD3delta promoter.
The Journal of biological chemistry - 6 Dec 2002
Ji Hong-Bin, Gupta Anita, Okamoto Susumu, Blum Michael D, Tan Lujian, Goldring Mary B, Lacy Elizabeth, Roy Ananda L, Terhorst Cox
Abstract excerpt
T cell-specific expression of human and mouse CD3delta is known to be governed by an enhancer element immediately downstream from the gene. Here we demonstrate by transgenic and in vitro studies that the murine CD3delta (mCD3delta) promoter prefers to be expressed in cells of the T lineage. Deletion analyses of a promoter segment (-401/+48 bp) followed by transient transfections indicate that upstream elements...
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