Article
Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis.
PloS one - 1 Jan 2013
Fang Jianzheng, Wang Shangqian, Zhang Shengli, Su Shifeng, Song Zhen, Deng Yunfei, Cui Hongqing, Wang Hainan, Zhang Yi, Qian Jian, Gu Jinbao, Liu Bianjiang, Li Pengchao, Zhang Rui, Liu Xinnong, Wang Zengjun
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible associations of the GSTM1 and GSTT1 null genotype in...
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