Article
Gene-drug interaction: additive influence of mutant APOA1 and testosterone on plasma HDL-cholesterol.
Clinical biochemistry - 1 Jul 2002
Keyhan Golyar, Rosset Jennifer, Wang Jian, Miller David, McManus Ruth, Hegele Robert A
Abstract excerpt
OBJECTIVES: Factors associated with decreased plasma high-density lipoprotein (HDL) cholesterol concentration, or hypoalphalipoproteinemia, include androgenic steroids and mutations in APOA1, encoding apolipoprotein (apo) A-I, the main structural protein of HDL. However, there is little information regarding the extent of plasma HDL lowering when exogenous testosterone is used in subjects with monogenic low HDL....
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