Human RNA-specific adenosine deaminase <i>ADAR1</i> transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

Abstract excerpt

RNA-specific adenosine deaminase (ADAR1) catalyzes the deamination of adenosine to inosine in viral and cellular RNAs. Two size forms of the ADAR1 editing enzyme are known, an IFN-inducible approximately 150-kDa protein and a constitutively expressed N-terminally truncated approximately 110-kDa protein. We have now identified alternative exon 1 structures of human ADAR1 transcripts that initiate from unique...

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