Article
Photocarcinogenesis: UVA vs. UVB radiation.
Skin pharmacology and applied skin physiology - 1 Jan 2000
de Gruijl Frank R
Abstract excerpt
Recent research is revealing combinations of disturbed oncogenic and tumor-suppressive signaling pathways by altered or missing genes in skin cancers: mutated PTCH (in the mitogenic Sonic Hedgehog pathway) and mutated p53 tumor suppressor gene in basal cell carcinomas (BCC), possibly an activated mitogenic RAS pathway and mutated p53 in squamous cell carcinomas (SCC), and possibly an activated MET/RAS pathway and...
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