Detection of three common translocation breakpoints in non‐Hodgkin's lymphomas by fluorescence in situ hybridization on routine paraffin‐embedded tissue sections

Abstract excerpt

Non-random chromosomal translocations are specifically involved in the pathogenesis of many non-Hodgkin's lymphomas and have clinical implications as diagnostic and/or prognostic markers. Their detection is often impaired by technical problems, including the distribution of the breakpoints over large genomic areas. This study reports a fluorescence in situ hybridization (FISH) method which allows the detection of...

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