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Article

Interphase FISH detection ofBCL2 rearrangement in follicular lymphoma using breakpoint-flanking probes

1 Jan 2000

Abstract excerpt

Rearrangement of the BCL2 gene is an important parameter for the differential diagnosis of non-Hodgkin lymphomas. Although a relatively large proportion of breakpoints is clustered, many are missed by standard PCR. A FISH assay is therefore desired. Up to now, a lack of probes flanking the BCL2 gene has limited the possibilities for a FISH assay to an approach based on colocalization of probes for BCL2 and the...

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PMID: 10564590
DOI: 10.1002/(sici)1098-2264(200001)27:1<85::aid-gcc11>3.0.co;2-9

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