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Article

Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations.

Protein science : a publication of the Protein Society - 1 Oct 2002

Piana Stefano, Carloni Paolo, Rothlisberger Ursula

Abstract excerpt

The emergence of drug-resistant variants is a serious side effect associated with acquired immune deficiency syndrome therapies based on inhibition of human immunodeficiency virus type 1 protease (HIV-1 PR). In these variants, compensatory mutations, usually located far from the active site, are able to affect the enzymatic activity via molecular mechanisms that have been related to differences in the...

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Identifiers

PMID: 12237461
DOI: 10.1110/ps.0206702
PMCID: PMC2384161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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