Mutations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in clinical strains of fluoroquinolone-resistant Shigella in Anhui, China.

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Article

Mutations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in clinical strains of fluoroquinolone-resistant Shigella in Anhui, China.

Journal of microbiology (Seoul, Korea) - 1 Apr 2007

Hu Li-Fen, Li Jia-Bin, Ye Ying, Li Xu

Abstract excerpt

In this research 26 Shigella isolates were examined by PCR and direct nucleotide sequencing for genetic alterations in the quinolone-resistance determining regions (QRDRs). We tested for the presence of qnr genes by PCR in 91 strains, but no qnr genes were found. The results did show, however, some novel mutations at codon 83 of gyrA (Ser-->Ile) and codon 64 of parC (Ala64-->Cys, Ala64-->Asp), which were related...

Topics

China
DNA Gyrase
DNA Topoisomerase IV
Drug Resistance, Bacterial
Dysentery, Bacillary
Fluoroquinolones
Humans
Molecular Sequence Data
Mutation
Protein Subunits
Shigella

Source

Open in PubMed

Identifiers

PMID: 17483803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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