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Article

Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2002

Lee Ho-Young, Suh Young-Ah, Lee Janet I, Hassan Khaled A, Mao Li, Force Thomas, Gilbert Brian E, Jacks Tyler, Kurie Jonathan M

Abstract excerpt

PURPOSE: Transfer of growth-suppressive genes to lung tumors has therapeutic potential, but effective delivery techniques have not been developed. Here, we investigated gene delivery to lung tumors by aerosolization of adenoviral vectors incorporated into calcium phosphate precipitates. EXPERIMENTAL DESIGN: To investigate the efficacy of this delivery method in normal and neoplastic lung, an adenoviral vector...

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PMID: 12231543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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