Article
Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer.
Anticancer research - 1 Dec 2010
Fukazawa Takuya, Maeda Yutaka, Matsuoka Junji, Ono Toshiro, Mominoki Katsumi, Yamatsuji Tomoki, Shigemitsu Kaoru, Morita Ichiro, Murakami Ichiro, Tanaka Hirotoshi, Durbin Mary L, Naomoto Yoshio
Abstract excerpt
Pulmonary surfactant has been used as a carrier to deliver a therapeutic virus to dysfunctional lung cells that reside within an intricate lung structure. To investigate whether pulmonary surfactant enhances the efficacy of intratracheal instillation of a therapeutic virus to target KRAS mutation-bearing lung cancer in vivo, we developed a recombinant adenovirus that induces cell death only in lung cancer cells...
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