Article
The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2002
Stephanou Anastasis, Scarabelli Tiziano M, Townsend Paul A, Bell Robert, Yellon Derek, Knight Richard A, Latchman David S
Abstract excerpt
We have demonstrated previously that the STAT-1 transcription factor plays a key role in ischemia/reperfusion (I/R)-induced apoptosis in cardiac myocytes. In the present study we assessed which region of the STAT-1 molecule mediates apoptosis in cardiac myocytes. A STAT-1 construct (amino acid 350-750) lacking the N-terminus could enhance I/R-induced apoptosis in cardiac myocytes. However, a STAT-1 construct,...
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