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Article

Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.

Molecular biology of the cell - 1 Sept 2002

Nürnberger Jens, Bacallao Robert L, Phillips Carrie L

Abstract excerpt

Nephrogenesis starts with the reciprocal induction of two embryonically distinct analages, metanephric mesenchyme and ureteric bud. This complex process requires the refined and coordinated expression of numerous developmental genes, such as inv. Mice that are homozygous for a mutation in the inv gene (inv/inv) develop renal cysts resembling autosomal-recessive polycystic kidney disease. The gene locus containing...

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Identifiers

PMID: 12221118
DOI: 10.1091/mbc.e02-04-0195
PMCID: PMC124145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.PMID 12221118Read ↗

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.Semantic proximity Read ↗

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathwaysSemantic proximity Read ↗

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing regionSemantic proximity Read ↗

Inversin relays Frizzled-8 signals to promote proximal pronephros developmentSemantic proximity Read ↗

The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.Semantic proximity Read ↗

The Invs gene encodes a microtubule-associated protein.Semantic proximity Read ↗

Sustained cell proliferation of renal epithelial cells in mice with inv mutation.Semantic proximity Read ↗

Renal cysts of inv/inv mice resemble early infantile nephronophthisis.Semantic proximity Read ↗

Cardiopulmonary malformations in the inv/inv mouse.Semantic proximity Read ↗

Identification of a novel ankyrin isoform (AnkG190) in kidney and lung that associates with the plasma membrane and binds alpha-Na, K-ATPase.Semantic proximity Read ↗

Characterization of Apin, a secreted protein highly expressed in tooth‐associated epitheliaSemantic proximity Read ↗

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