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Article

Bone morphogenetic protein receptor-II mutation Arg491Trp causes malignant phenotype of familial primary pulmonary hypertension.

Biochemical and biophysical research communications - 19 Mar 2004

Zhicheng Jing, Lihe Lu, Zhiyan Han, Xiansheng Cheng, Yubao Zou, Yuejin Yang, Rutai Hui

Abstract excerpt

A four-generation pedigree of familial primary pulmonary hypertension (FPPH) with 14 alive members was collected. In the family, three of the 14 alive familial members were diagnosed as FPPH. Mutations in bone morphogenetic protein receptor-II (BMPR-II) gene were screened by using sequencing analysis. A C-to-T transition at position 1471 in exon 11 of the BMPR-II gene was identified, resulting in an Arg491Trp...

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Identifiers

PMID: 14985116
DOI: 10.1016/j.bbrc.2004.01.158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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