Article
Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface.
The Journal of biological chemistry - 6 Dec 2002
Graille Marc, Harrison Steven, Crump Matthew P, Findlow Stuart C, Housden Nicholas G, Muller Bruno H, Battail-Poirot Nicole, Sibaï Geneviève, Sutton Brian J, Taussig Michael J, Jolivet-Reynaud Colette, Gore Michael G, Stura Enrico A
Abstract excerpt
The multidomain bacterial surface protein L (PpL) is a virulence factor expressed by only 10% of Peptostreptococcus magnus strains, and its expression is correlated with bacterial vaginosis. The molecular basis for its ability to recognize 60% of mammalian immunoglobulin light chain variable regions (V(L)) has been described recently by x-ray crystallography, which suggested the presence of two V(L) binding sites...
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