Article
Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2002
Tomaszewski Maciej, Brain Nick J R, Charchar Fadi J, Wang William Y S, Lacka Beata, Padmanabahn Sandosh, Clark James S, Anderson Niall H, Edwards Helen V, Zukowska-Szczechowska Ewa, Grzeszczak Wladyslaw, Dominiczak Anna F
Abstract excerpt
A region on human chromosome 5 (5q31.1-qter) contains several genes that encode important blood pressure regulators and thus is a good candidate for analysis of linkage and association with hypertension. We recruited 638 individuals from 212 Polish pedigrees with clustering of essential hypertension. These subjects were genotyped for 11 microsatellite markers that span this region to test for linkage to essential...
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