Article
Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans.
Genome research - 1 Sept 2002
Steen Barbara R, Lian Tian, Zuyderduyn Scott, MacDonald William Kim, Marra Marco, Jones Steven J M, Kronstad James W
Abstract excerpt
The basidiomycete fungus Cryptococcus neoformans is an opportunistic pathogen of worldwide importance that causes meningitis, leading to death in immunocompromised individuals. Unlike many basidiomycete fungi, C. neoformans is thermotolerant, and its ability to grow at 37 degrees C is considered to be a virulence factor. We used serial analysis of gene expression (SAGE) to characterize the transcriptomes of C....
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