Article
Characterisation of mutations in GroES that allow GroEL to function as a single ring.
FEBS letters - 21 Jul 2009
Liu Han, Kovács Eszter, Lund Peter A
Abstract excerpt
The chaperonin GroEL contains two seven-subunit rings, and allosteric signals between them are required to complete the GroEL reaction cycle. For this reason SR1, a mutant of GroEL that forms only single rings, cannot function as a chaperone. Mutations in SR1 that restore chaperone function weaken its interaction with the cochaperonin GroES. We predicted that GroES mutants with reduced affinity for GroEL would...
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