Article
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
International journal of cancer - 10 Sept 2002
Leonard J Helen, Cook Anthony L, Van Gele Mireille, Boyle Glen M, Inglis Kelly J, Speleman Frank, Sturm Richard A
Abstract excerpt
Merkel cells form part of the peripheral neuroendocrine system of the skin and act as mechanoreceptors in touch response. Merkel cell carcinoma (MCC) is a rare, aggressive disease with similarities to small cell lung cancer (SCLC), which is also of neuroendocrine origin. We previously identified a novel DNA binding protein complex specific for MCC suspension cell lines, termed Merkel nuclear factor (MNF) by its...
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