Article
Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma.
Oncogene - 8 Apr 2004
Van Gele Mireille, Boyle Glen M, Cook Anthony L, Vandesompele Jo, Boonefaes Tom, Rottiers Pieter, Van Roy Nadine, De Paepe Anne, Parsons Peter G, Leonard J Helen, Speleman Frank
Abstract excerpt
Merkel cell carcinoma (MCC) is a rare aggressive skin tumor which shares histopathological and genetic features with small-cell lung carcinoma (SCLC), both are of neuroendocrine origin. Comparable to SCLC, MCC cell lines are classified into two different biochemical subgroups designated as 'Classic' and 'Variant'. With the aim to identify typical gene-expression signatures associated with these phenotypically...
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