Sequence Requirements for Viral RNA Replication and VPg Uridylylation Directed by the Internal <i>cis</i> -Acting Replication Element ( <i>cre</i> ) of Human Rhinovirus Type 14

Abstract excerpt

Until recently, the cis-acting signals required for replication of picornaviral RNAs were believed to be restricted to the 5' and 3' noncoding regions of the genome. However, an RNA stem-loop in the VP1-coding sequence of human rhinovirus type 14 (HRV-14) is essential for viral minus-strand RNA synthesis (K. L. McKnight and S. M. Lemon, RNA 4:1569-1584, 1998). The nucleotide sequence of the apical loop of this...

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