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Article

Epidemic pathogenic selection: an explanation for hereditary hemochromatosis?

Medical hypotheses - 1 Sept 2002

Moalem Sharon, Percy Maire E, Kruck Theo P A, Gelbart Richard R

Abstract excerpt

Hereditary hemochromatosis (HH) is a disorder associated with progressive iron overload and deposition in multiple organs. It is the most common inherited single gene disorder in people of Northern and Western European descent. About 80% of individuals of European descent with HH are homozygous for a cysteine-to-tyrosine substitution (C282Y) in the gene now called HFE. The function of HFE protein, a major...

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Source

Identifiers

PMID: 12208162
DOI: 10.1016/s0306-9877(02)00179-2

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heterozygosity for the C282Y mutation in the hemochromatosis gene is associated with increased serum iron, transferrin saturation, and hemoglobin in young women: a protective role against iron deficiency?Semantic proximity Read ↗

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