Article
Hereditary Hemochromatosis Predisposes Mice to Yersinia pseudotuberculosis Infection Even in the Absence of the Type III Secretion System.
Frontiers in cellular and infection microbiology - 1 Jan 2016
Miller Halie K, Schwiesow Leah, Au-Yeung Winnie, Auerbuch Victoria
Abstract excerpt
The iron overload disorder hereditary hemochromatosis (HH) predisposes humans to serious disseminated infection with pathogenic Yersinia as well as several other pathogens. Recently, we showed that the iron-sulfur cluster coordinating transcription factor IscR is required for type III secretion in Y. pseudotuberculosis by direct control of the T3SS master regulator LcrF. In E. coli and Yersinia, IscR levels are...
Topics
- Animals
- Disease Models, Animal
- GPI-Linked Proteins
- Genetic Diseases, Inborn
- Genetic Predisposition to Disease
- Hemochromatosis
- Hemochromatosis Protein
- Macrophages
- Membrane Proteins
- Mice, Knockout