Article
Population genetic implications from DNA polymorphism in random human genomic sequences.
Human mutation - 1 Sept 2002
Shen Peidong, Buchholz Molly, Sung Raphael, Roxas Adriane, Franco Claudia, Yang Wei-Hsien, Jagadeesan Raja, Davis Karen, Oefner Peter J
Abstract excerpt
Denaturing high performance liquid chromatography (DHPLC) in combination with dye-terminator sequencing was used to survey 516 random genomic sequence tagged sites (STSs) for biallelic polymorphisms in 24 representatives of the major ethnic groups residing in the United States. Of the 301 polymorphic STSs (58.3%), 172 contained a single simple sequence polymorphism (SSP), while 78, 35, and 16 contained 2, 3, and...
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