Article
Ascidian otx gene Hroth activates transcription of the brain-specific gene HrTRP.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2002
Wada Shuichi, Toyoda Reiko, Yamamoto Hiroaki, Saiga Hidetoshi
Abstract excerpt
The brain (sensory vesicle) of the ascidian larvae is thought to be homologous to the vertebrate forebrain and midbrain and, thus, is proposed as a simplified model to investigate mechanisms of brain formation in vertebrates. However, the genetic circuitry that governs formation of the sensory vesicle is largely unknown. To address this issue, we investigated the transcriptional regulation of the sensory...
Topics
- Animals
- Binding Sites
- Brain
- Cytochalasin B
- Genes, Reporter
- Homeodomain Proteins
- In Situ Hybridization
- Lac Operon
- Oligonucleotides, Antisense
- Open Reading Frames
- Otx Transcription Factors