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Article

CpG hypermethylation of promoter region and inactivation of E‐cadherin gene in human bladder cancer

1 Aug 2002

Abstract excerpt

Several studies have shown that E-cadherin expression is lost during malignant transformation. We hypothesized that CpG methylation in the promoter region may inactivate the expression of the E-cadherin gene in human bladder cancer. Normal and bladder cancer samples from 51 patients were compared in terms of E-cadherin gene expression and methylation status by immunohistochemistry, methylation-specific polymerase...

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Share to Bladder and Urothelial Cancer Treatments
Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation

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PMID: 12203370
DOI: 10.1002/mc.10064

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