Article
Characterization of hepatitis C virus quasispecies by matrix-assisted laser desorption ionization-time of flight (mass spectrometry) mutation detection.
Journal of clinical microbiology - 1 Sept 2002
Ayers Melissa, Siu Karen, Roberts Eve, Garvin Alex M, Tellier Raymond
Abstract excerpt
Hepatitis C virus (HCV), the causative agent of hepatitis C, frequently causes chronic infection. The mechanisms of viral persistence continue to be the object of investigation. An important aspect of HCV chronic infection is the quasispecies nature of the viral population, which has been particularly well documented in the hypervariable region 1 of the E2 glycoprotein. Recent studies show that characterization...
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