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A pathology of the sperm centriole responsible for defective sperm aster formation, syngamy and cleavage

29 Aug 2002

Abstract excerpt

BACKGROUND: In the present report we analyse the structural and functional features of sperm from a patient with severe asthenoteratozoospermia and failure of cleavage after ICSI. METHODS: Sperm were studied by phase contrast and transmission electron microscopy and microinjected into bovine oocytes to examine aster formation using antibodies against acetylated alpha- and beta-tubulins. RESULTS: Acephalic sperm,...

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PMID: 12202423
DOI: 10.1093/humrep/17.9.2344

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