Article
Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae.
The Journal of biological chemistry - 15 Nov 2002
Cabiscol Elisa, Bellí Gemma, Tamarit Jordi, Echave Pedro, Herrero Enrique, Ros Joaquim
Abstract excerpt
In the present study, we have analyzed the role of the molecular chaperone Hsp60 in protection of Saccharomyces cerevisiae against oxidative damage. We constructed mutant strains in which the levels of Hsp60 protein, compared with wild-type cells, were four times greater, and the addition of doxycycline gradually reduces them to 20% of wild-type. Under oxidative-stress conditions, the progressive decrease in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.